Nature

JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21

Cyclin D-CDK4/6 are the first cyclin-dependent kinase (CDK) complexes to be activated by mitogenic/oncogenic pathways. They have a central role in the cell multiplication decision and in its ...
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A novel function for cyclin D1 as a transcriptional role in oncogenesis and tumor development by ChIP-Seq and RNA-Seq.

Characterization of OASEP1 as a biomarker and therapeutic target for oral cancer. Impact on U251 glioma cell radiosensitivity and CFL1 level via inhibiting cell motility regulator ROCKII of ...
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Loss of Pin1 Function in the Mouse Causes Phenotypes Resembling Cyclin D1-Null Phenotypes

This is a preview. Log in through your library . Abstract Phosphorylation of proteins on serine/threonine residues preceding proline is a key signaling mechanism. The conformation and function of a ...
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DNA Tumor Virus Oncoproteins and Retinoblastoma Gene Mutations Share the Ability to Relieve the Cell's Requirement for Cyclin D1 Function in G1

This is a preview. Log in through your library . Abstract The retinoblastoma gene product (pRB) participates in the regulation of the cell division cycle through complex formation with numerous ...
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A novel function for cyclin D1 as a transcriptional role in oncogenesis and tumor development by ChIP-Seq and RNA-Seq.

Survival data following phase 1/2 studies using precision tumor-targeted gene delivery to advanced chemotherapy-resistant malignancies. This is an ASCO Meeting Abstract from the ASCO Breakthrough: A ...