Protein kinase signaling along the kinetochore–centromere axis is crucial to assure mitotic fidelity, yet the details of its spatial coordination are obscure. Here, we examined how pools of human Polo ...

The Sli15-Ipl1-Bir1 chromosomal passenger complex is essential for proper kinetochore--microtubule attachment and spindle stability in the budding yeast Saccharomyces cerevisiae. During early anaphase ...

Thousands of our cells successfully divide every day. They replicate their DNA and then separate so that each of the new cells has the same complement of chromosomes. If the process goes wrong and ...

As a cell divides, its DNA -the genetic material- is duplicated and condensed into structures called chromosomes, which are carefully organized and distributed so that each daughter cell acquires a ...