Courtesy of Linda B. Schultz CHECK POINT: The 53Bp1-dependent checkpoint pathway. DNA double-strand breaks are caused by irradiation and other geotoxic events. The ATM [ataxia-telangiectasia mutated] ...
DNA polymerase θ (POLθ), repressed in somatic cells and overexpressed in several types of cancer, is crucial for DNA double-strand break repair during mitosis.
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