Osteoarthritis can be a debilitating disease, rendering regular movements painful. Researchers have now identified a signaling pathway that transmits this pain, with a study in mice finding that ...

The hormone estrogen—which female animals typically have more of than males—triggers a molecular cascade in the gut that ...

Researchers integrated four organoids that represent the four components of the human sensory pathway, along which pain signals are conveyed to the brain. Stimulation of the sensory organoid (top) by ...

Stanford Medicine investigators have replicated, in a lab dish, one of the most prominent human nervous pathways for sensing pain. This nerve circuit transmits sensations from the body’s skin to the ...

New research reveals previously unknown ways opioid receptors can function, opening the door to safer pain treatments.

Scientists created a model of the human pain pathway in a dish by connecting four separate brain organoids. The feat should help them understand sensory disorders like those affecting pain perception.

For decades, opioids have been the blunt instrument of modern pain care, powerful enough to quiet severe suffering yet risky ...

Researchers have discovered that a particular molecular signaling pathway plays an important role in producing osteoarthritis (OA) pain. Using a mouse model of painful osteoarthritis, they show that ...

The American College of Cardiology (ACC) expert decision pathway for chest pain can safely and effectively rule out acute coronary syndromes in most patients, but not for those with known coronary ...

Researchers studying the human brain shared a lot of fascinating research this year, like how to keep brains young and how to reduce inflammation in joints.

Scientists have re-created a pain pathway in the brain by growing four key clusters of human nerve cells in a dish. This laboratory model could be used to help explain certain pain syndromes, and ...