BC200 is a long non-coding RNA (lncRNA) that has been implicated in the regulation of protein synthesis, yet whether dysregulation of BC200 contributes to the pathogenesis of human diseases remains ...

In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists from Nagoya University, Japan, led by Associate Professor Akio Masuda, have recently identified the ...

Alternative splicing is a fundamental biological process that allows cells to make many different types of mRNAs and proteins from a limited number of genes. For many animals, including humans, it is ...

Abstract Alternative splicing (AS) is a crucial regulatory mechanism in eukaryotes, which acts by greatly increasing transcriptome diversity. The extent and complexity of AS has been revealed in model ...

The enormous cellular diversity in the mammalian brain, which is highly prototypical and organized in a hierarchical manner, is dictated by cell-type–specific gene-regulatory programs at the molecular ...

Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...

A recent study by TUS researchers reveal that the Cpeb4 protein may have a role in regulating osteoclast differentiation. This, in turn, could lead to the development of new therapeutic drugs for ...

RNA splicing is a major nexus of gene expression regulation, shaping cellular identity during development, frequently altered in human cancers. This process is mediated by a complex molecular ...

Large versus limited molecular profiling panel screening program in patients with metastatic sarcoma: An exploratory subgroup analysis from the ProfiLER 02 trial. This is an ASCO Meeting Abstract from ...

New research has identified sections of DNA associated with altered regulation of gene expression underlying schizophrenia. The implicated loci contribute to schizophrenia risk by affecting ...

Although heart cells and skin cells contain identical instructions for creating proteins encoded in their DNA, they’re able to fill such disparate niches because molecular machinery can cut out and ...