Describe Merrifield solid phase synthesis for preparation of th... | Filo
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Describe the Merrifield solid-phase synthesis when carried out ... | Filo
Describe the Merrifield solid-phase synthesis when carried out ... | Filo
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Solid-Phase Peptide Synthesis: The Merrifield Method - SlideServe
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SOLVED: The fluorenylmethoxycarbonyl group is used to protect the amino group of amino acids during the Merrifield solid phase peptide synthesis procedure. The group is then removed by treatment with piperidine. The mechanism of addition and removal is as follows:The amino acid under basic conditions reacts with Fmoc chloride followed by deprotonation to give a tetrahedral intermediate I. The collapse of the tetrahedral intermediate gives the Fmoc-aa. In the removal sequence, deprotonation of th
SOLVED: The fluorenylmethoxycarbonyl group i…
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